<html><body><div style="color:#000; background-color:#fff; font-family:arial, helvetica, sans-serif;font-size:12pt"><div><span>Oi Fernando!!</span></div><div><br><span></span></div><div><span>Poisé, eu já conheço o cross-over. O problema foi justamente o que vc falou, faltou o wash-out. Mais estes tipos de pesquisas acredito que não dê para fazer o wash-out, pois precisa tratar o animal logo (devido ao câncer). Dê uma olhada em parte dos dados originais. É aquele velho problema Fernando por parte dos pesquisadores. A FALTA de PLANEJAMENTO. Aí nos procuram querendo os resultados pra ontem. Já passou da hora dos estatísticos entrarem no início da pesquisa e não quando a casa está caindo como é de costume. Bom, dá uma olhada aí. <br></span></div><div><span><br></span></div><div><span>Abraços!</span></div><div><br><span></span></div><div><br><span></span></div><div>
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<colgroup><col width="151"><col width="108"><col width="100"><col width="192"></colgroup>
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<td style="border: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" width="151" align="CENTER"><b><font color="#000000">ANIMAL</font></b></td>
<td style="border-top: 3px solid rgb(58, 57, 53); border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" width="108" align="CENTER"><b><font color="#000000">DATA</font></b></td>
<td style="border-top: 3px solid rgb(58, 57, 53); border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" width="100" align="CENTER"><b><font color="#000000">MUCOSAS</font></b></td>
<td style="border-top: 3px solid rgb(58, 57, 53); border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" width="192" align="CENTER"><b><font color="#000000">LINFONODOS</font></b></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">25/05/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">HIPOC.</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">01/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><font color="#000000">03/06/2011</font></td>
<td style="border: 3px solid rgb(58, 57, 53);" colspan="17" valign="TOP" align="LEFT"><font color="#000000">INÍCIO DO TRATAMENTO (GEL)</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000">MENINA</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">08/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">HIPOC.</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">15/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">HIPOC.</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">22/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">29/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">06/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><font color="#000000">11/07/2011</font></td>
<td style="border: 3px solid rgb(58, 57, 53);" colspan="17" valign="TOP" align="LEFT"><font color="#000000">INICIO DO TRATAMENTO COM VINCRISTINA</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">13/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="41" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">20/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">LEVEMENTE HIPOC.</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">27/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="41" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">03/08/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">HIPOCORADAS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><font color="#000000">08/08/2011</font></td>
<td style="border: 3px solid rgb(58, 57, 53);" colspan="25" valign="TOP" align="LEFT"><font color="#000000">TÉRMINO DO TRATAMENTO COM VINCRISTINA </font></td>
</tr>
<tr>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="41" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ccff"><font color="#000000">10/08/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ccff"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ccff"><font color="#000000">SUBMANDIBULAR ESQ.</font></td>
</tr>
<tr>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-left: 3px solid rgb(58, 57, 53);" valign="TOP" align="LEFT"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53);" valign="TOP" align="LEFT"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53);" valign="TOP" align="LEFT"><font color="#000000"><br></font></td>
</tr>
<tr>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="41" valign="TOP" align="CENTER"><b><font color="#000000">ANIMAL</font></b></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><b><font color="#000000">DATA</font></b></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><b><font color="#000000">MUCOSAS</font></b></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><b><font color="#000000">LINFONODOS</font></b></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">25/05/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">01/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ffff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><font color="#000000">03/06/2011</font></td>
<td style="border: 3px solid rgb(58, 57, 53);" colspan="17" valign="TOP" align="LEFT"><font color="#000000">INÍCIO DO TRATAMENTO (GEL)</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="41" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">08/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">INGUINAL AUMENTADO</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000">LILI</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">15/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">22/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">29/06/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">06/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ff00"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER"><font color="#000000">11/07/2011</font></td>
<td style="border: 3px solid rgb(58, 57, 53);" colspan="17" valign="TOP" align="LEFT"><font color="#000000">INICIO DO TRATAMENTO COM VINCRISTINA</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">13/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">20/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
</tr>
<tr>
<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="21" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">27/07/2011</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#ff0000"><font color="#000000">NORMAIS</font></td>
</tr>
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<td style="border-left: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" height="41" valign="TOP" align="CENTER"><font color="#000000"><br></font></td>
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<td style="border-bottom: 3px solid rgb(58, 57, 53); border-right: 3px solid rgb(58, 57, 53);" valign="TOP" align="CENTER" bgcolor="#00ccff"><font color="#000000">MAMARIO DIR.</font></td>
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</div><div> <br><br></div><div style="background-color: transparent;" align="center"><font style="background-color: transparent;" face="comic sans ms" size="2"><font size="1"><b><br></b></font></font></div><div style="text-align: left; background-color: transparent;" align="center"><font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif" size="2">\begin{signature}</font></font></div><div style="text-align: left; background-color: transparent;" align="center"><font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif" size="2"><<>>=</font></font></div><div style="text-align: left; background-color: transparent;" align="center"><font class="Apple-style-span" face="courier, monaco, monospace, sans-serif" size="2">Prof. Dr. Ivan Bezerra Allaman</font></div><div style="text-align: left; background-color: transparent;" align="center"><font class="Apple-style-span"
face="courier, monaco, monospace, sans-serif" size="2">Universidade Estadual de Santa Cruz</font></div><div style="text-align: left; background-color: transparent;" align="center"><font class="Apple-style-span" face="courier, monaco, monospace, sans-serif" size="2">Departamento de Ciências Exatas e Tecnológicas</font></div><div style="text-align: left; background-color: transparent;" align="center"><font class="Apple-style-span" face="courier, monaco, monospace, sans-serif" size="2">Ilhéus/BA - Brasil</font></div><div style="text-align: left; background-color: transparent;" align="center"><font class="Apple-style-span" face="courier, monaco, monospace, sans-serif" size="2">Fone: +55 73 3680-5076</font></div><div style="text-align: left; background-color: transparent;" align="center"><font class="Apple-style-span" face="courier, monaco, monospace, sans-serif" size="2">E-mail: ivanalaman@yahoo.com.br/ivanalaman@gmail.com</font></div><div
style="text-align: left; background-color: transparent;" align="center"><font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif" size="2">@</font></font></div><div style="text-align: left; background-color: transparent;" align="center"><font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif" size="2">\end{signature}</font></font></div><div><br></div> <div style="font-family: arial,helvetica,sans-serif; font-size: 12pt;"> <div style="font-family: times new roman,new york,times,serif; font-size: 12pt;"> <font face="Arial" size="2"> <hr size="1"> <b><span style="font-weight: bold;">De:</span></b> Fernando Colugnati <fernando@ipti.org.br><br> <b><span style="font-weight: bold;">Para:</span></b> r-br@listas.c3sl.ufpr.br; Ivan Bezerra Allaman <ivanalaman@yahoo.com.br> <br> <b><span style="font-weight: bold;">Enviadas:</span></b> Sábado, 17 de Dezembro de 2011
20:17<br> <b><span style="font-weight: bold;">Assunto:</span></b> Re: [R-br] Medidas repetidas na mesma unidade experimental!!<br> </font> <br><div id="yiv73321706">Oi Allaman, isso tem mais cara de um delineamento Cross-over. Acho estranho apenas o fato dos tratamentos serem trocados sem um preíodo de washout, que seria para livrar o cão de qualquer efeito do tratamento anterior, evitando contaminação.<div>
Se não foi feito isso, não sei se há variável latente que consiga captar este problema...mas posso estar enganado.<div><br><div>Dá uma olhada nisso :</div><div><br></div><div><span class="yiv73321706Apple-style-span" style="font-family: sans-serif; font-size: 13px; line-height: 19px; background-color: rgb(255, 255, 255);">Vonesh, Edward F.; Chinchilli, Vernon G. (1997). "Crossover Experiments". </span><i style="font-family: sans-serif; font-size: 13px; line-height: 19px; background-color: rgb(255, 255, 255);"><a rel="nofollow" target="_blank" href="http://en.wikipedia.org/wiki/Linear_model" title="Linear model" style="text-decoration: none; color: rgb(6, 69, 173); background-image: none;">Linear</a> and <a rel="nofollow" target="_blank" href="http://en.wikipedia.org/wiki/Nonlinear_regression" title="Nonlinear regression" style="text-decoration: none; color: rgb(6, 69, 173); background-image: none;">Nonlinear</a> <a rel="nofollow"
target="_blank" href="http://en.wikipedia.org/wiki/Statistical_model" title="Statistical model" style="text-decoration: none; color: rgb(6, 69, 173); background-image: none;">Models</a> for the <a rel="nofollow" target="_blank" href="http://en.wikipedia.org/wiki/Statistical_inference" title="Statistical inference" style="text-decoration: none; color: rgb(6, 69, 173); background-image: none;">Analysis</a> of <a rel="nofollow" target="_blank" href="http://en.wikipedia.org/wiki/Repeated_measures_design" title="Repeated measures design" style="text-decoration: none; color: rgb(6, 69, 173); background-image: none;">Repeated Measurements</a></i><span class="yiv73321706Apple-style-span" style="font-family: sans-serif; font-size: 13px; line-height: 19px; background-color: rgb(255, 255, 255);">. London: Chapman and Hall. pp. 111–202.</span></div>
<div><font class="yiv73321706Apple-style-span" face="sans-serif"><span class="yiv73321706Apple-style-span" style="line-height: 19px;">ou</span></font></div><div><span class="yiv73321706Apple-style-span" style="font-family: sans-serif; font-size: 13px; line-height: 19px; background-color: rgb(255, 255, 255);">Jones, Byron; Kenward, Michael G. (2003). </span><i style="font-family: sans-serif; font-size: 13px; line-height: 19px; background-color: rgb(255, 255, 255);">Design and Analysis of Cross-Over Trials</i><span class="yiv73321706Apple-style-span" style="font-family: sans-serif; font-size: 13px; line-height: 19px; background-color: rgb(255, 255, 255);"> (Second ed.). London: Chapman and Hall.</span></div>
<div><font class="yiv73321706Apple-style-span" face="sans-serif"><span class="yiv73321706Apple-style-span" style="line-height: 19px;">ou este mais seminal</span></font></div><div><font class="yiv73321706Apple-style-span" face="sans-serif"><span class="yiv73321706Apple-style-span" style="line-height: 19px;"><br>
</span></font></div><div><div class="yiv73321706hd yiv73321706title" style="margin: 0px; padding: 0px 4px 2px 0.01em; background-image: none; background-color: rgb(255, 255, 255); font-size: 13px; font-weight: bold; font-family: Arial,Helvetica,sans-serif;">
The Crossover Experiment for Clinical Trials</div><div class="yiv73321706bd" style="margin: 0px; padding: 0px 0px 2px; font-family: Arial,Helvetica,sans-serif; font-size: 12px; line-height: 14px; background-color: rgb(255, 255, 255);">
<div class="yiv73321706author" style="margin: 0px; padding: 0px 0px 2px;">Byron Wm. Brown, Jr.</div><div class="yiv73321706srcInfo" style="margin: 0px; padding: 0px 0px 2px;">
<cite>Biometrics</cite><br>Vol. 36, No. 1 (Mar., 1980), pp. 69-79 <br>(article consists of 11 pages)</div></div></div><div><font class="yiv73321706Apple-style-span" face="sans-serif"><span class="yiv73321706Apple-style-span" style="line-height: 19px;"><br>
</span></font></div><div><font class="yiv73321706Apple-style-span" face="sans-serif"><span class="yiv73321706Apple-style-span" style="line-height: 19px;">Att</span></font></div><div><br><div class="yiv73321706gmail_quote">Em 17 de dezembro de 2011 19:39, Ivan Bezerra Allaman <span dir="ltr"><<a rel="nofollow" ymailto="mailto:ivanalaman@yahoo.com.br" target="_blank" href="mailto:ivanalaman@yahoo.com.br">ivanalaman@yahoo.com.br</a>></span> escreveu:<br>
<blockquote class="yiv73321706gmail_quote" style="margin: 0pt 0pt 0pt 0.8ex; border-left: 1px solid rgb(204, 204, 204); padding-left: 1ex;"><div><div style="color: rgb(0, 0, 0); background-color: rgb(255, 255, 255); font-family: arial,helvetica,sans-serif; font-size: 12pt;"><div><span>Boa noite senhores!</span></div>
<div><br><span></span></div><div><span>Há alguns dias estou estudando a metodologia de medidas repetidas em uma mesma unidade experimental ao longo do tempo, com o intuito de ajudar uma pesquisadora. Encontrei materiais, livros, artigos, etc que me dão segurança em trabalhar com tal medotologia. No entanto, há uma dúvida que me deixou num impasse, e preciso da ajuda dos colegas mais experientes que trabalham com estes tipos de dados. O objetivo da pesquisadora foi avaliar o uso de dois tratamentos sobre a redução de um tumor cancerígeno em cães do sexo feminino. Inúmeras variáveis (nominais, contínuas, etc.) foram avaliadas (secreção, leucócitos, etc.). As medidas foram tomadas em um mesmo animal ao longo de um período de 30 dias. Até aí tudo bem. Pois posso utilizar a
abordagem de modelos mistos considerando o animal como de efeito aleatório, e no modelo incluir uma estrutura de correlação do tipo Arima, sarima, entre outros. Ainda estou avaliando qual melhor estrutura. Mas a dúvida crucial é que além de ter tomadas várias medidas num mesmo animal, este mesmo animal recebeu mais de um tratamento. Por exemplo: Do dia 1 ao dia 15 recebeu o tratamento A e do dia 16 ao dia 30 o tratamento B. Aí que estou encontrando problema, pois creio que há efeitos residuais do tratamento A sobre o B, confundindo os verdadeiros efeitos de cada tratamento. Uma saída, seria tratar os dois tratamentos como apenas um. Alguém já trabalhou com estrutura semelhante? Alguém poderia me recomendar uma literatura para que eu possa ganhar mais este desafio?</span></div>
<div><br><span></span></div><div><span>Desde já, agradeço a atenção de
todos!</span></div><div><br><span></span></div><div><span>Abraços!</span></div><div><br><span></span></div><div><span>(S,f,P)</span></div><div><span>Allaman</span></div><div> </div><div style="background-color: transparent;" align="center">
<font style="background-color: transparent;" face="comic sans ms" size="2"><font size="1"><b><br></b></font></font></div><div style="text-align: left; background-color: transparent;" align="center"><font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif">\begin{signature}</font></font></div>
<div style="text-align: left; background-color: transparent;" align="center"><font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif"><<>>=</font></font></div><div style="text-align: left; background-color: transparent;" align="center">
<font face="courier, monaco, monospace, sans-serif">Prof. Dr. Ivan Bezerra Allaman</font></div><div style="text-align: left; background-color: transparent;" align="center"><font face="courier, monaco, monospace, sans-serif">Universidade Estadual de Santa Cruz</font></div>
<div style="text-align: left; background-color: transparent;" align="center"><font face="courier, monaco, monospace, sans-serif">Departamento de Ciências Exatas e Tecnológicas</font></div><div style="text-align: left; background-color: transparent;" align="center">
<font face="courier, monaco, monospace, sans-serif">Ilhéus/BA - Brasil</font></div><div style="text-align: left; background-color: transparent;" align="center"><font face="courier, monaco, monospace, sans-serif">Fone: <a rel="nofollow">+55 73 3680-5076</a></font></div>
<div style="text-align: left; background-color: transparent;" align="center"><font face="courier, monaco, monospace, sans-serif">E-mail: <a rel="nofollow" target="_blank" href="http://ivanalaman@yahoo.com.br/ivanalaman@gmail.com">ivanalaman@yahoo.com.br/ivanalaman@gmail.com</a></font></div>
<div style="text-align: left; background-color: transparent;" align="center"><font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif">@</font></font></div><div style="text-align: left; background-color: transparent;" align="center">
<font style="background-color: transparent;"><font face="courier, monaco, monospace, sans-serif">\end{signature}</font></font></div></div></div><br>_______________________________________________<br>
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